细胞和分子的关联与内在的大脑组织
Guozheng Feng1, Jiayu Chen1, Jing Sui2
1Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA.
bioRxiv : the preprint server for biology
|September 18, 2025
概括
大脑的细胞和分子组织与其功能网络保持一致. 这种微观架构影响大规模的大脑功能和认知.
科学领域:
- 神经科学是一个神经科学.
- 计算生物学 计算生物学
- 系统神经科学 系统神经科学
背景情况:
- 了解细胞/分子架构与人类大脑功能之间的关系至关重要.
- 目前的研究缺乏全面整合多模式数据,以将微观组织与宏观功能联系起来.
研究的目的:
- 研究细胞和分子特征如何与人类大脑中的内在连接网络 (ICNs) 空间相对应.
- 确定微尺度架构是否可以预测大规模的功能网络组织和认知过程.
主要方法:
- 转录组 (微阵列,snRNA-seq),分子成像和神经成像数据集的整合.
- 分析细胞类型,神经递质系统,线粒体表型和ICN之间的空间对应.
- 调解分析探索微尺度架构,功能网络连接 (FNC) 和认知之间的关系.
主要成果:
- 观察到细胞类型分布,神经递质系统,线粒体表型和ICN之间的空间对齐.
- 细胞和分子相似性网络总结了功能网络连接模式和规范功能域.
- 发现ICN和FNC能够调解微观组织与认知过程之间的联系.
结论:
- 大脑的功能架构是系统地组织,与其细胞和分子构成保持一致.
- 这种微观组织可能会限制功能网络的形成,并为认知的神经基础做出贡献.
相关概念视频
Organization of the Brain
2.3K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
2.3K
Assembly of Complex Microtubule Structures
2.4K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
2.4K
Cerebrum: Anatomical Overview II
4.4K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
4.4K
Functional Brain Systems: Reticular Formation
4.4K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
4.4K
Association Areas of the Cortex
8.9K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
8.9K
Functional Brain Systems: Limbic System
6.6K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
6.6K


