在动物,灵长类动物和人类之间进行皮层和皮层下灰色物质分片的等级框架
Siva Venkadesh1, Yuhe Tian1, Wen-Jieh Linn2
1Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
bioRxiv : the preprint server for biology
|September 18, 2025
概括
这项研究为动物,非人类灵长类动物和人类创建了一个统一的大脑地图,使得大脑组织和进化的跨物种比较成为可能. 共同的地图集强调了物种之间保存和分歧的大脑结构.
科学领域:
- 神经科学是一个神经科学.
- 比较解剖学的比较.
- 脑部成像 脑部成像
背景情况:
- 翻译神经科学需要共同的解剖学框架来进行跨物种大脑比较.
- 目前的物种特异性地图书阻碍了比较分析.
- 大脑大小和专业化的差异使物种间研究复杂化.
研究的目的:
- 为动物,非人类灵长类动物和人类开发一个分层的共同大脑地图.
- 为了使跨物种对大脑组织进行比较分析.
- 为神经科学研究提供统一的坐标系统.
主要方法:
- 为三个物种构建了人口平均最小变形模板.
- 开发了一个使用地标指导边界的等级共同地图.
- 采用多模式非线性注册用于解剖对齐.
- 验证了与物种特定地图集相对应的地图集.
主要成果:
- 在共同的地图集和特定物种的地图集之间实现了强大的区域对应.
- 识别了跨物种的系统体积缩放.
- 在人类中观察到扩大的关联皮层.
- 在动物中注意到对边缘和感官运动区域的重视.
结论:
- 开发的共同地图集为比较神经科学提供了一个统一的坐标系统.
- 促进跨物种成像,发育研究和连接学.
- 支持对保存和分离的大脑组织的调查.
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