在输入输出响应中,激活时间和稳定状态水平之间的脱
Giorgio Ravanelli1,2, Kee-Myoung Nam3, Jeremy Gunawardena3
1CRG (Barcelona Collaboratorium for Modelling and Predictive Biology), C/ Dr Aiguader 88, 08003, Barcelona, Spain.
bioRxiv : the preprint server for biology
|September 18, 2025
概括
研究人员探索了生物系统中的输出脱,发现输入度可以在不改变激活时间的情况下改变响应水平. 这种现象可以通过利率尺度的分离或不连贯的监管机制来解释.
科学领域:
- 系统生物学 系统生物学
- 生物物理学的生物物理.
- 分子生物学分子生物学
背景情况:
- 生物过程涉及到与目标结合的分子输入,触发下游反应.
- 由转录因子 (TF) 调节的基因可以表现出输出脱,在这种情况下,更高的TF度会增加转录而不会改变激活时间.
研究的目的:
- 在马尔科夫过程模型中研究输出脱的机制.
- 确定稳定状态读出水平随输入度而变化,但激活时间保持不变的条件.
主要方法:
- 利用马尔科夫过程模型的分析和数值研究.
- 模拟的读出分子生产下游的带结合.
主要成果:
- 确定了两种输出脱机制:利率尺度的分离和不连贯的监管.
- 速率尺度分离涉及输入差异调节缓慢和快速的系统转换.
- 不连贯的监管涉及影响两个过渡的输入,对读出产产生相反的影响.
结论:
- 输出脱可能来自于利率尺度的分离或不连贯的监管.
- 不连贯的监管,一个合理的TF监管模式,可能以输出脱为特征.
- 为理解输入-输出系统中的输出脱提供了一个框架.
更多相关视频
10:45Time-dependent Increase in the Network Response to the Stimulation of Neuronal Cell Cultures on Micro-electrode Arrays
Published on: May 29, 2017
10.3K
07:41Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
Published on: June 5, 2017
10.3K
相关概念视频
01:24Transient and Steady-state Response
513
In control systems, test signals are essential for evaluating performance under various conditions. The ramp function is effective for systems undergoing gradual changes, while the step function is suitable for assessing systems facing sudden disturbances. For systems subjected to shock inputs, the impulse function is the most appropriate test signal.
These test signals are integral in designing control systems to exhibit two key performance aspects: transient response and steady-state...
These test signals are integral in designing control systems to exhibit two key performance aspects: transient response and steady-state...
513
01:21First Order Systems
399
First-order systems, such as RC circuits, are foundational in understanding dynamic systems due to their straightforward input-output relationship. Analyzing their responses to different input functions under zero initial conditions reveals significant insights into system behavior.
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
399
01:18Second Order systems II
389
In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
389
01:13Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model
292
Drugs administered through various routes can lead to nonlinear elimination, resulting in complex pharmacokinetic behaviors crucial to understanding efficacious drug dosing.
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
292
01:31Classification of Systems-II
460
Continuous-time systems have continuous input and output signals, with time measured continuously. These systems are generally defined by differential or algebraic equations. For instance, in an RC circuit, the relationship between input and output voltage is expressed through a differential equation derived from Ohm's law and the capacitor relation,
460
01:15RC Circuit with Source
2.6K
When a DC source is abruptly applied to an RC (Resistor-Capacitor) circuit, the voltage can be represented as a unit step function. The voltage across the capacitor, known as the step response, characterizes how the circuit reacts to this sudden change in input.
Due to the inherent properties of a capacitor, its voltage cannot change instantaneously. This means that immediately after the switch is closed, the capacitor's voltage remains the same as it was just before the switch was closed.
Due to the inherent properties of a capacitor, its voltage cannot change instantaneously. This means that immediately after the switch is closed, the capacitor's voltage remains the same as it was just before the switch was closed.
2.6K