Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Exploring wild rices for photosynthetic efficiency improvement in rice.

Physiology and molecular biology of plants : an international journal of functional plant biology·2026
Same author

A genetic reporter for visualizing nitroreductase activity using magnetic resonance imaging.

Chemistry methods : new approaches to solving problems in chemistry·2026
Same author

The Dawn till Dusk of phytopharmaceuticals.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society·2026
Same author

Assessment of the Potential of Different Anthropometric Indices in Predicting the Risk of Diabetes and Associated Co-morbidities.

Metabolic syndrome and related disorders·2026
Same author

Metabolic profiling and biological studies of <i>Aegle marmelos</i> enriched fractions: a potential source for pharmaceuticals and nutraceuticals.

Natural product research·2026
Same author

A novel dual-energy cone beam computed tomography device for assessment of jaw bone density.

Oral radiology·2026

相关实验视频

Updated: May 12, 2026

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
10:07

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

1.7K

一个可编程的遗传平台,用于设计非侵入性的生物传感器.

Asish N Chacko1, Kaamini M Dhanabalan2, Jinyang Wan1

  • 1Department of Chemistry, University of California, Santa Barbara, CA 93106, USA.

bioRxiv : the preprint server for biology
|September 18, 2025
PubMed
概括
此摘要是机器生成的。

研究人员开发了基于通用记者电路的可激活传感器 (URCAS) 来创建遗传MRI传感器. 该平台可在深层组织中进行生物活动的非侵入性可视化,用于研究和诊断.

关键词:
这就是为什么MRI是MRI.在水中,有水.生物传感器生物传感器蛋白酶电路中的蛋白质酶.记者基因 记者基因

更多相关视频

Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol
08:04

Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol

Published on: November 3, 2023

2.4K
Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

611

相关实验视频

Last Updated: May 12, 2026

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
10:07

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

1.7K
Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol
08:04

Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol

Published on: November 3, 2023

2.4K
Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

611

科学领域:

  • 生物医学工程 生物医学工程
  • 分子成像学分子成像学
  • 基因工程是一种基因工程.

背景情况:

  • 对深层组织生物活动的非侵入性可视化对于研究和治疗至关重要.
  • 磁共振成像 (MRI) 提供高分辨率,无辐射的深层组织成像,但缺乏可适应的遗传对比方法.
  • 将分子事件与遗传编码的MRI对比度联系起来,是生物分子技术的一个重大挑战.

研究的目的:

  • 引入一个可编程平台,通用报告器基于电路的可激活传感器 (URCAS),用于创建MRI的遗传传感器.
  • 通过蛋白质稳定和亚细胞贩运来设计可激活蛋白酶的MRI记者.
  • 为了证明URCAS对各种生物点的多功能性,而无需进行广泛的定制.

主要方法:

  • 开发了基于电路的可激活传感器 (URCAS) 平台的通用报告器.
  • 通过蛋白质稳定和亚细胞贩运来设计可激活蛋白酶的MRI记者.
  • 在五种哺乳动物细胞类型中测试了URCAS的适用性,并为各种目标创建了传感器.

主要成果:

  • 成功建立了URCAS在五种不同的哺乳动物细胞类型中的适用性.
  • 通过创建病毒蛋白,药物,逻辑门,蛋白相互作用和的遗传传感器来证明URCAS的多功能性.
  • 展示了在没有针对特定目标的定制的情况下开发传感器的能力.

结论:

  • URCAS为开发遗传MRI传感器提供了一个模块化和可编程的平台.
  • 这个平台简化了生物医学研究的非侵入性,非离子化传感器的创建.
  • 乌尔卡斯具有推动体内诊断和基于细胞的疗法的潜力.