母亲饮食与儿童肥胖之间的代际关联:贝叶斯规范化调解分析
Yu-Bo Wang1, Cuilin Zhang2, Zhen Chen2
1School of Mathematical and Statistical Sciences, Clemson University, Clemson, USA.
Statistics in biosciences
|September 18, 2025
概括
孕妇的代谢健康和怀孕期间的饮食显著影响儿童肥胖风险. 这项研究确定了影响儿童体重指数 (BMI) z-分数的关键母亲因素,有助于预防策略.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 生物统计学 生物统计学
背景情况:
- 儿童肥胖与晚年慢性疾病有关.
- 妊娠并发症,如妊娠期糖尿病和母亲的饮食,与儿童肥胖风险增加有关.
- 传统分析往往忽略了涉及多个因素的复杂调解途径.
研究的目的:
- 开发和应用一个新的调解分析框架,用于多次暴露和调解者.
- 为了确定影响儿童体重指数 (BMI) z-score的特定母亲风险因素.
- 为制定针对儿童肥胖的有针对性的预防计划提供信息.
主要方法:
- 使用规范化的两阶段方法进行多次暴露和调解者的调解分析.
- 采用缩先验来选择重要的直接和间接影响途径.
- 将该方法应用于来自丹麦国家出生队列 (DNBC) 的数据.
主要成果:
- 确定了6个显著的孕产妇风险因素,影响7岁儿童BMIz-score.
- 这些因素对儿童BMI产生了直接和间接的影响.
- 模拟证实了拟议模型的良好性能.
结论:
- 开发的调解分析模型有效地确定了影响儿童肥胖的关键母亲途径.
- 研究结果为设计有效的公共卫生干预措施来打击儿童肥胖提供了关键的见解.
- 了解这些复杂的关系对于改善长期儿童健康结果至关重要.
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