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充填模块化,生物可降解和生物兼容的眼镜插件,用于通过直接粉末挤出3D打印进行调节性阿西克洛维尔释放
Ankan Das1, Srushti Lekurwale1, Shriram Mahajan2
1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam 781101, India.
Molecular pharmaceutics
|September 18, 2025
概括
直接粉末挤出3D打印创建可溶解的眼内插件,持续释放阿西克洛维尔,改善疹性角膜炎的治疗. 这些以患者为中心的插件提供了增强的药物透和保留,提高了合规性.
科学领域:
- 眼科医生 眼科 眼科
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
背景情况:
- 传统的疹性角膜炎治疗面临着诸如快速消除药物和患者不良坚持等挑战.
- 需要持续释放的眼部药物输送系统来提高治疗疗效和患者的遵从性.
研究的目的:
- 使用直接粉末挤出 (DPE) 3D打印开发和表征持续释放,可溶解的阿西克洛维尔眼内插件.
- 评估灌注密度对药物释放动力学,角膜穿透和生物相容性的影响.
主要方法:
- 通过DPE3D打印制作含有阿西克洛维尔的眼镜插件,其填充密度不同 (30%,60%,90%).
- 在体外释放药物的研究,透角膜透测定和生物相容性评估 (HET-CAM,血液相容性,细胞活力).
- 同焦激光扫描显微镜 (CLSM) 评估药物透和保留在角膜层.
主要成果:
- 填充密度较低的插件显示了更快的侵蚀和更高的阿西克洛维尔释放 (在24小时内约95%),增强了横角膜透.
- 填充密度较高的插件释放速度较慢 (在24小时内约58%),透率降低.
- 所有配方都表现出良好的生物相容性,生理pH值,灵活性和韦布尔释放动力学,3D打印插件显示显著增强的角膜透和保留.
结论:
- DPE3D打印是一种可行的方法,用于创建可定制的,可生物腐蚀的眼镜插件,用于持续的药物输送.
- 这些插件有可能通过量身定制的释放,增强的角膜保留和更好的患者遵守来改善疹性角膜炎的治疗.
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