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对比剂对甲状腺功能的短期影响:一个前性队列研究
Lingling Peng1, Shujin Fan2, Feifei Lai3
1Department of Pharmacy, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
含的对比介质 (ICM) 可以导致暂时的甲状腺功能障碍,特别是在患有甲状腺结节的患者中. 大多数中国患者在对比剂暴露后一个月内自然恢复.
科学领域:
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 在医学成像过程中使用含的对比剂 (ICM) 存在过量摄入的风险.
- 在中国人群中,ICM对甲状腺功能的潜在短期影响尚不清楚.
研究的目的:
- 研究ICM暴露对中国人口甲状腺功能的短期影响.
- 为了确定尿液中含量与对比剂剂量之间的关系.
- 评估ICM暴露后甲状腺功能恢复的情况.
主要方法:
- 在200名接受静脉注射ICM的患者中,甲状腺功能在暴露前,1周和输液后1个月被评估.
- 分析了尿液中度 (UIC) 和对比剂 (CA) 的剂量.
- 患有甲状腺功能障碍的患者被跟踪了3个月.
主要成果:
- 尿中的水平在ICM后1周达到峰值,与自由甲状腺素 (FT4) 呈现微弱的正相关性.
- 较高的对比剂剂量与较低的抗甲状腺过氧化酶抗体 (TPOAb) 水平存在弱相关性.
- 患有甲状腺结节的患者患甲状腺功能障碍症的风险增加 (OR = 2.1491,p=0.0465).
结论:
- 暴露于ICM可以暂时增加亚临床甲状腺功能障碍的风险,特别是在患有先前存在甲状腺结节的患者中.
- 观察到的甲状腺功能异常通常是暂时的,大多数患者在没有干预的情况下在3个月内自发恢复.
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