2型糖尿病和甲状腺癌之间的共同分子机制:为预后生物标志物发现提供综合生物信息学的见解
Jiahui Qi1, Chuanzhi Chen2, Feng Zhu3
1Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Endocrine connections
|September 18, 2025
概括
2型糖尿病 (T2D) 和甲状腺癌 (TC) 具有共同的遗传联系,特别是在代谢途径上. 像PRDM1和ZFPM2这样的特定基因可能为糖尿病患者的甲状腺癌提供新的治疗点.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 基因组学就是基因组学.
背景情况:
- 甲状腺癌 (TC) 发病率在全球范围内不断上升,特别是在女性中.
- 2型糖尿病 (T2D) 越来越多地与TC相关,可能是由于高胰岛素血症,胰岛素抵抗和炎症.
- T2D和TC之间的分子联系需要进一步阐明.
研究的目的:
- 确定TC和T2D之间共享的分子机制和差异表达基因 (DEGs).
- 探索功能途径和潜在的预后生物标志物连接这两种疾病.
- 为分层TC患者开发基因风险模型.
主要方法:
- 来自TC和T2D的基因表达综合 (GEO) 数据库的转录组数据集的综合分析.
- 使用功能丰富分析,蛋白质-蛋白质相互作用网络和Cox回归.
- 开发了一个基于已识别的DEGs的预后风险模型.
主要成果:
- 在TC和T2D之间确定了28个共享的DEG,突出显示CD44,TGFBI,RUNX2和GJA1作为关键的枢纽基因.
- 凯格路径分析显示了细胞粘附,细胞外矩阵重塑和NF-κB信号的参与.
- 一个七基因风险模型成功地将TC患者分为高风险和低风险组,具有显著的生存差异 (P = 0.017).
结论:
- 在T2D和TC之间存在重叠的遗传失调,影响代谢重编程和瘤微环境.
- 在T2D患者中,PRDM1和ZFPM2成为TC的潜在治疗点.
- 了解这些共享的途径可以为共患T2D和TC提供有针对性的治疗方法.
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