孕妇头三个月血清维生素A/E度和12个月内婴儿亚托皮炎的风险
Ying Ye1,2, Yuanzhou Peng2,3, Yi Zhang2
1Department of Dermatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
概括
在怀孕早期,母体血清中维生素E含量较高与婴儿亚托皮炎 (AD) 的风险较低有关. 这表明维生素E可能有助于预防婴儿的AD.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 母亲的抗氧化维生素摄入量与婴儿亚托皮炎 (AD) 之间的联系尚未完全理解.
- 关于母亲血清维生素水平及其对婴儿AD风险的影响的数据有限.
研究的目的:
- 为了研究母亲血清维生素A和E水平在妊娠的第一季度和随后的婴儿AD的风险之间的联系.
- 量化特定维生素度与后代阿尔茨海默氏症发展之间的关系.
主要方法:
- 进行了一项包括456名孕妇在内的队列研究.
- 测量母亲血清维生素A (视网醇) 和维生素E (α-托科菲罗尔) 使用液态染色体质谱法在怀孕的第一季度.
- 婴儿AD发病率从出生到12个月使用多变量离散时间生存分析跟踪.
主要成果:
- 121名婴儿 (26.5%) 发展为AD.
- 每增加1微克/毫升的母体血清维生素E与婴儿AD风险降低8%相关 (aHR=0.92).
- 母亲的维生素A水平与婴儿AD风险没有显著关联.
结论:
- 怀孕早期母亲血清维生素E水平升高与婴儿AD风险降低有线联系.
- 怀孕期间母亲足够的维生素E水平可能在预防婴儿AD方面发挥作用.
- 进一步的研究可以探索有针对性的维生素E补充策略.
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