过早的心室收缩位置和事件心力衰竭
Thomas A Dewland1, David G Rosenthal1, Edward P Gerstenfeld1
1Department of Internal Medicine, Division of Cardiology, Electrophysiology Section, University of California-San Francisco, San Francisco, California, USA.
JACC. Clinical electrophysiology
|September 18, 2025
概括
来自左心室或上心脏的早发性心室收缩 (PVC) 会增加心力衰竭的风险. 这项研究分析了大量人群中的PVC来源,发现特定位置与更高的心力衰竭发病率有关.
科学领域:
- 心脏病学 心脏病学
- 流行病学 流行病学
- 电子生理学 电子生理学
背景情况:
- 过早心室收缩 (PVC) 的解剖分布及其与心力衰竭风险的关联在一般人群中未得到充分研究.
- 之前的研究主要集中在与心律失常相关的现有疾病患者身上.
研究的目的:
- 描述PVC来源的流行病学.
- 确定PVCs的解剖位置是否独立地与患心力衰竭的风险有关.
主要方法:
- 从CHS和ARIC队列中分析没有流行心力衰竭的门诊成年人.
- 由专家评审人员使用基线12导电心电图 (ECG) 形态评估解剖学PVC位置.
主要成果:
- 在20,590名参与者中,有2.1%的人有PVC. 最常见的来源是左心室 (49%),外流通道 (27%) 和右心室 (22%).
- 在19.2年的时间里,PVC与心力衰竭风险增加有关 (HR: 1.43).
- 来自上心层 (HR:2.98) 和左心室 (HR:1.59) 的PVC显示出发生性心力衰竭的最高调整风险.
结论:
- 在大量人群中,心室外皮通常位于左心室.
- 来自左心室和上心脏区域的PVC与发生性心力衰竭的风险显著增加有关.
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