在中国中老年和老年人中,体重,腰围或两者的变化与意外心力衰竭有关
1Department of Occupational and Environment Health. Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Journal of cachexia, sarcopenia and muscle
|September 18, 2025
概括
体重和腰围的变化在老年人中显著影响心力衰竭风险. 过度体重增加和腰围增加会增加风险,而腰围减少可能会降低风险.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 老年学是一门学科.
背景情况:
- 较高的体重和腰围与心力衰竭风险增加有关.
- 体重和腰围的变化随着时间的推移而发生.
- 这些变化对中年和老年人心力衰竭风险的综合影响仍未得到充分研究.
研究的目的:
- 调查体重和腰围的综合变化与发生心力衰竭之间的关联.
- 分析体重和腰围变化对心力衰竭风险的独立和联合影响.
- 探索人体测量变化与心力衰竭发病率之间的非线性关系.
主要方法:
- 对45620名中国成年人 (年龄在45-104岁) 进行前性研究,在基线时没有严重疾病.
- 体重和腰围的变化被分类为6至7年的时间.
- 考克斯比例危险回归模型和受限立方脊柱分析被用来评估与心力衰竭的关联,平均随访时间为9.66年.
主要成果:
- 过度体重增加与心力衰竭风险增加27%有关 (HR,1.27).
- 过度的腰围增加增加了28%的心力衰竭风险 (HR, 1.28),而过度的腰围损失降低了24%的风险 (HR, 0.76).
- 组合变化,如减轻体重与过度增腰,显示显著增加风险 (HR, 2.19).
结论:
- 过度体重增加和腰围增加是心力衰竭的独立危险因素.
- 过度的腰围损失可能会对心力衰竭产生保护作用.
- 综合的人类测量变化提供了对心力衰竭风险分层的更细致的理解.
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