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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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我们从EUSTAR数据库中了解了什么关于全身性硬化症?

Corrado Campochiaro1, Madelon C Vonk2, Thomas Osborne3

  • 1Unit of Immunology, Rheumatology, Allergy and Rare Diseases. San Raffaele Hospital. and Vita-Salute San Raffaele University, Milano, Italy.

Current opinion in rheumatology
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PubMed
概括
此摘要是机器生成的。

欧洲硬化硬化体试验和研究 (EUSTAR) 数据库是系统性硬化症 (SSc) 的全球注册表,提供了有价值的现实数据. 这些发现为临床实践,研究和针对罕见疾病的个性化医学提供了信息.

关键词:
在EUSTAR数据库中.队列 队列 队列 队列系统性硬化症 系统性硬化症

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科学领域:

  • 风湿病学和免疫学
  • 罕见疾病研究研究.
  • 临床数据科学临床数据科学

背景情况:

  • 欧洲硬化硬化体试验和研究 (EUSTAR) 数据库是世界上最大的系统性硬化症 (SSc) 国际注册表.
  • 它包含了超过27,000名患者的纵向数据,收集了20多年的全球合作.
  • 欧星对于了解罕见疾病至关重要,特别是对现实世界的数据和精准医学的兴趣日益增加.

研究的目的:

  • 综合来自EUSTAR数据库的关键发现.
  • 突出注册表对系统性硬化症研究和临床实践的贡献.
  • 概述未来利用这一独特数据集的方向.

主要方法:

  • 审查和分析来自EUSTAR国际注册表的数据.
  • 纵向数据收集和患者注册量每年超过1000名新患者.
  • 应用创新的研究方法,包括模拟临床试验和比较有效性分析.

主要成果:

  • 澄清系统性硬化症表型,疾病轨迹以及器官干扰和死亡率的预测因素.
  • 验证结果指标,如EUSTAR活动指数.
  • 识别治疗模式的异质性,细化分类标准和区域护理差异.

结论:

  • 欧星作为罕见病协作研究的基准.
  • 登记处的发现直接影响系统性硬化症管理指南和临床实践.
  • 未来的数字工具和人工智能的整合将加强其在临床试验设计和个性化医疗中的作用.