重新评估诺普拉赞对内镜阴性反流性疾病:系统性审查和元分析
Minahil Iqbal1, Muhammad Ahsan Asif1, Asma Tahir1
1Department of Medicine, Allama Iqbal Medical College, Lahore, 54550, Pakistan.
Digestive diseases and sciences
|September 18, 2025
概括
诺普拉赞10毫克对非侵蚀性反流性疾病 (NERD) 没有任何益处. 然而,Vonoprazan 20 mg适度增加了没有烧的日子,具有类似的安全性,这表明在NERD患者中具有潜在的疗效.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 非侵蚀性反流性疾病 (NERD) 缺乏食道侵蚀,使其与侵蚀性食道炎 (EE) 不同.
- 沃诺普拉赞是一种与具有竞争力的酸阻断剂,用于EE治疗.
- 诺普拉桑在NERD管理中的有效性仍在研究中.
研究的目的:
- 系统地审查和元分析随机对照试验 (RCT).
- 在被诊断为NERD的患者中,与安慰剂相比,评估vonoprazan的疗效和安全性.
主要方法:
- 在MEDLINE,Embase和Cochrane图书馆进行系统的文献搜索,直到2025年1月25日.
- 包括在NERD患者中将vonoprazan与安慰剂进行比较的所有RCT.
- 使用风险比率 (RRs) 和标准化平均差异 (SMDs) 与95%置信区间 (CI) 的二进制和连续结果的聚合分析.
主要成果:
- 分析了四项涉及2540名患者的RCT.
- 与安慰剂相比,Vonoprazan 10 mg在胃灼热症状控制和不良事件方面没有显著差异.
- 伏诺普拉赞20毫克显著增加了无日数 (SMD:0.13;p=0.03),安全性与安慰剂相比相当.
结论:
- 诺普拉桑10毫克在治疗NERD方面并不优于安慰剂.
- 诺普拉桑20毫克在增加NERD患者的无日方面表现出适度的疗效.
- 诺普拉桑20毫克剂量为NERD提供了一个潜在的治疗选择,具有可接受的安全性.
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