"在被挖掘的住院患者中检测镇静剂和抗精神病药物:法医毒理学案例系列"
Gianmarco Argentiero1, Luca Morini2, Marcello Benevento3
1Department of Legal Medicine and Forensic Sciences, University of Pavia, Via Forlanini n. 12, Pavia, 27100, Italy. gianmarco.argentiero@gmail.com.
Forensic science, medicine, and pathology
|September 18, 2025
概括
在被挖掘的老年人中,死后毒理学是具有挑战性的,因为分解. 在没有医疗记录的情况下检测米达佐拉姆和普罗玛等镇静剂和抗精神病药物,引发了对未经授权的管理的担忧.
科学领域:
- 法医毒理学 法医毒理学
- 验尸调查 验尸后的调查
- 老年人药理学 老年人药理学
背景情况:
- 挖掘的尸体对毒理学分析提出了重大挑战.
- 长期护理中的老年人可能有复杂的药物历史,有时从记录中省略.
- 对潜在的未经授权的药物管理的担忧需要专门的法医分析.
研究的目的:
- 调查分解的挖掘尸体中是否存在镇静剂和抗精神病药物.
- 评估死后毒理学对此类病例的方法和解释方面的困难.
- 在司法背景下评估检测到的药物水平与死亡原因之间的潜在联系.
主要方法:
- 完整的法医尸检,包括外部检查和生物样本采集.
- 使用气体染色学-质谱学 (GC-MS) 和液体染色学-双重质谱学 (LC-MS/MS) 的毒理学分析.
- 量化毒理学结果的评估与病理学发现一起进行.
主要成果:
- 先进的分解影响了所有15例病例,限制了形态和组织学分析.
- 在各种组织中检测到米达佐拉姆,其代谢物α-hydroxy-midazolam和promazine.
- 只有一个病例有记录的处方;14个病例缺乏检测到的药物的治疗理由.
结论:
- 解读分解的挖掘尸体中的药物含量受到死后再分配和物质不稳定性的限制.
- 毒理学发现,没有医学理由,可能表明未经授权的管理,但不证实死亡的因果关系.
- 为了准确的法医解释,需要对分解组织中的药物行为进行进一步的研究.
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