腹膜透析患者的真菌腹膜炎:全国范围的队列研究
Margarita Kunin1, Tatiana Tanasiychuk2, Nabil Abu-Amer3
1Nephrology and Hypertension Institute, Sheba Medical Center and the Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel. Margarita.Kunin@sheba.health.gov.il.
概括
腹膜透析 (PD) 患者的真菌腹膜炎的预后不佳,通常需要取出导管,导致高死亡率. 最近的细菌腹膜炎和多次使用抗生素是显著的危险因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 真菌腹膜炎是腹膜透析 (PD) 的严重并发症.
- 它与高发病率,死亡率和治疗失败有关.
- 这项研究调查了其临床过程,风险因素和成年PD患者的结果.
研究的目的:
- 评估成年PD患者的真菌腹膜炎的临床特征,易感因素和结果.
- 为了确定与PD患者的真菌腹膜炎相关的风险因素.
主要方法:
- 一项全国性的回顾性研究在以色列进行了十多年.
- 分析了被诊断患有真菌腹膜炎的成年PD患者的数据.
- 收集和检查了临床,微生物学和结果数据.
主要成果:
- 确定了40名患有真菌性腹膜炎的患者,Candida物种是最常见的病原体 (82.5%).
- 观察到高住院率 (95%),克霍夫导管切除 (90%) 和死亡率 (27.5%).
- 以前的细菌性腹膜炎 (55%) 和最近接触多种抗生素 (62.5%) 是常见的;多种抗生素使用是一个独立的危险因素 (OR 1.940).
结论:
- 在PD患者的真菌腹膜炎与预后不佳有关.
- 最近复杂的细菌腹膜炎和广泛的抗生素暴露是显著的易感因素.
- 这些发现强调了需要在PD患者中谨慎管理和预防策略.
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