对1型糖尿病和胃肠道病症患者进行重复的便微生物群移植
Katrine L Høyer1,2,3, Ditte S Kornum4,5,6, Simon M D Baunwall4,5
1Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark. kathoeye@rm.dk.
Diabetologia
|September 18, 2025
概括
重复的便微生物群移植 (FMT) 在1型糖尿病患者中为糖尿病胃肠病症症状提供长期缓解. 这种安全有效的治疗方法可以在长时间内改善肠道健康和患者满意度.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 糖尿病胃肠病症显著影响生活质量.
- 便微生物群移植 (FMT) 显示出缓解症状的前景.
- 暂时的缓解需要探索维持治疗策略.
研究的目的:
- 评估重复,按需FMT的长期疗效和安全性.
- 评估FMT作为糖尿病胃肠病的维持疗法的可行性.
- 为了确定患者的满意度和治疗效益在长时间的随访期间.
主要方法:
- 17名参与者参与的开放式扩展研究,来自先前的FMT试验.
- 通过GSRS-IBS进行症状评估,每2-3个月进行一次评分.
- 监测了肠道排便频率,便一致性 (布里斯托尔便量表) 和不良事件 (AE).
主要成果:
- 观察到持续的症状缓解,平均GSRS-IBS得分在治疗后显著下降.
- 肠道排便频率和便一致性的改善在多个FMT周期中是一致的.
- 报告的参与者满意度很高 (86%),通常是轻微的和自我限制的不良事件.
结论:
- 重复,按需的FMT是一种安全有效的长期治疗选择.
- 在1型糖尿病患者中,FMT显著改善了胃肠道症状和生活质量.
- 这种治疗是可行的,并且可以很好地容忍维持治疗.
相关概念视频
What is Monogastric Digestion?
75.0K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
75.0K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
644
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
644
Drugs for Treatment of Diarrhea-Predominant IBS
635
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
635


