瘤学中的疲劳经验;一个有针对性的定性文献评论和以患者为中心的新概念模型
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Chloe Carmichael1, Cecile Gousset2, Danielle Burns1
1Clinical Outcomes Assessment, Clarivate Analytics, London, UK.
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|September 18, 2025
概括
与癌症相关的疲劳对患者产生重大影响.
科学领域:
- 在瘤学瘤学.
- 患者报告的结果
- 定性研究是一种定性研究.
背景情况:
- 传统的瘤学终点侧重于生存,往往忽视患者报告的疲劳等症状.
- 疲劳是一种常见但被低估的症状,影响癌症患者的生活质量 (QoL).
- 了解患者的疲劳经验对于改善测量和护理至关重要.
研究的目的:
- 描述患者对癌症相关疲劳的体验.
- 探索疲劳对患者情绪和日常功能的影响,包括与健康相关的生活质量 (HRQoL).
- 为未来在瘤学临床试验中测量疲劳的策略提供信息.
主要方法:
- 2018年至2023年间发表的关于癌症相关疲劳的定性研究的有针对性的文献综述.
- 在MEDLINE,Embase和PsycINFO进行了搜索.
- 用定性内容分析技术对提取的概念和患者报价进行二次分析.
主要成果:
- 分析了26项涉及28种癌症类型的512名患者的研究.
- 疲劳触发因素包括癌症治疗和疾病本身,表现为能量低,疲劳和疲.
- 与癌症相关的疲劳对患者的QOL (情绪,身体,社会,日常活动,睡眠,工作) 有负面影响,对医疗保健专业人员的支持有未满足的需求.
结论:
- 疲劳是跨越各种瘤学征兆的一个显著,具有影响力的症状.
- 该研究提出了癌症相关疲劳的第一个整体概念模型.
- 未来的研究应该评估临床结果评估 (COA) 用于测量瘤学试验中的疲劳.
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