相关实验视频

Updated: Jan 17, 2026

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

SGLT2抑制剂与生殖器癌症之间的关联:一个元分析和孟德尔随机化研究

Bo Xu^1,2,3,4,5,6, Yilin Liu^1,2,3,4,6, Zunbo He^7,8,9,10

¹The First Affiliated Hospital, Hunan Provincial Clinical Medical Research Center for Drug Evaluation of Major Chronic Diseases, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.

Journal of endocrinological investigation

|September 18, 2025

概括

-葡萄糖共运输体2 (SGLT2) 抑制剂对大多数生殖器癌症具有中性风险. 然而,根据遗传证据,SGLT2抑制可能会降低子宫癌风险.

科学领域:

在瘤学瘤学.
药理学药理学是指药理学的学科.
遗传学遗传学是一个

背景情况:

-葡萄糖共运输体2 (SGLT2) 抑制剂与生殖器癌症风险之间的关联尚未得到充分证实.
这项研究解决了围绕SGLT2抑制剂对各种生殖器癌症的影响的不确定性.

研究的目的:

研究SGLT2抑制剂和SGLT2抑制对发生生殖器癌症的风险的影响.
分析SGLT2抑制剂关于生殖器区域瘤结果的安全性.

主要方法:

对大型随机对照试验进行主要数据库 (PubMed,科学网,临床试验注册) 的系统文献搜索.
使用Mantle-Haenszel方法计算风险比率 (RRs) 和几率比率 (ORs) 的元分析,使用95%的置信区间 (CI).
孟德尔随机化研究利用SLC5A2中的遗传变异来评估SGLT2抑制和生殖器癌症之间的因果关系.

主要成果:

在15项研究 (16项试验) 中,SGLT2抑制剂在101,430名患者中显示出发生生殖器癌症的中性整体风险 (RR 1.10;95% CI 0.93-1.31).
对于宫癌,子宫内膜癌,卵巢癌,前列腺癌,子宫癌,阴茎癌或癌没有观察到显著的影响;然而,达帕格利弗洛辛显示男性生殖器癌症风险的潜在增加 (RR 1.31;95% CI 0.99-1.74).
抑制SGLT2显著降低了丸癌的风险 (OR 0.012;95% CI 0.001-0.220) 并显示出对宫癌的强烈保护作用 (OR 0.013;95% CI 0.001-0.122).

结论:

-葡萄糖共运输体2 (SGLT2) 抑制剂对生殖器癌症具有中立的整体风险概况.
遗传证据强烈支持SGLT2抑制对降低子宫癌风险的有益作用.
可能需要进一步的研究来探索不同类型的生殖器癌症中的特定药物效应和机制.

关键词:

宫癌是发生在宫癌的原因之一.生殖器癌症是生殖器癌症.抑制了SGLT2的发生.SGLT2 抑制剂的使用.

更多相关视频

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

相关概念视频

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Mutagenicity and Carcinogenicity

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...