吸收性腹膜透析技术的进步:一个叙述性回顾
Susan Bríd McGrath1, Pauline Kosalka2, Marjorie W Foo3
1Nephrology Department, London Health Sciences Center, London, Ontario, Canada.
概括
吸附剂腹腔透析 (SPD) 设备在治疗脏疾病方面表现有前途,几种模型展示了有效的废物清除和液体管理. 需要进一步对人体进行试验,以确定它们在透析治疗中的作用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物医学工程 生物医学工程
- 医疗器械 医疗器械
背景情况:
- 吸附剂腹腔透析 (SPD) 使用吸附剂层再生透析液,为传统透析方法提供了潜在的替代方案.
- 已经开发和研究了几种SPD设备,包括AWAK (Viva Kompact),Carry Life,WEAKID,ViWAK和Renart-PD.
研究的目的:
- 根据已发表的文献,审查和比较五种SPD设备的设计,透析清除和超能力.
- 评估这些设备在治疗病中的当前状态和潜力.
主要方法:
- 关于五种SPD设备的已发表研究 (人体试验,动物研究,体外数据) 的文献综述.
- 对透析清除 (溶液去除) 和超过 (液体去除) 能力的报告数据的分析.
主要成果:
- 所有审查的设备都显示出透析清除能力.
- 软体和运行寿命PD显示了高溶解物梯度;Viva Kompact和Renart-PD报告了血清废物标记的减少.
- 维瓦克有效地去除了肌素和其他溶液. 携带生命UF和Viva Kompact显示出显著的UF容量,每克使用的葡萄糖效率有所提高.
结论:
- SPD 设备具有在透析中有效的废物清除和流体管理的潜力.
- 虽然有希望,但许多设备缺乏全面的人体试验数据,特别是在UF容量方面.
- 大规模的人体研究对于确定这些SPD设备在腹膜透析中的未来临床作用至关重要.
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