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Updated: Jan 17, 2026

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T细胞内在的cGAS-CTCF调节维持了调节性T细胞的发育和功能

Hongpeng Li1, Yuchen Zhang2, Shangze Gao2

  • 1State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorous chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, China; School of Medicine, Tsinghua University, Beijing 100084, China.

Cell reports
|September 18, 2025
PubMed
概括

这项研究揭示了循环GMP-AMP合成酶 (cGAS) 在调节性T (Treg) 细胞发育和适应性免疫功能中起着至关重要的作用. 核cGAS增强Treg细胞活性,影响瘤免疫力,独立于STING.

关键词:
CP: 免疫学 免疫学在CTCF中,CTCF是指CTCF.在T ((reg) 中使用.这是TNFRSF.cGAS 是一个气体.染色素相互作用的相互作用

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