在眼中,X链介质驱动的单细胞后果
Peter D Price1, Sylvie M Parkus1, Victoria J Lloyd1
1Ecology and Evolutionary Biology, School of Biosciences, University of Sheffield, Sheffield, United Kingdom.
PLoS genetics
|September 18, 2025
概括
与性别相关的介质驱动因素会影响后代的性别比率. 这项研究揭示了它们对使用单细胞RNA测序的茎眼对男性生育能力和性染色体调节的影响.
科学领域:
- 进化遗传学的进化遗传学
- 生殖生物学 生殖生物学
- 基因组学就是基因组学.
背景情况:
- 与性别相关的介质驱动因素影响性别比率和基因组进化.
- 了解它们的分子基础仅限于少数模型生物.
- 在自然界中存在各种繁殖模式和驱动系统.
研究的目的:
- 在马来西亚眼 (Teleopsis dalmanni) 中调查一个与性别相关的介质驱动器.
- 描述男性生殖腺的细胞和转录格局.
- 确定介质驱动对精子生成和性染色体调节的影响.
主要方法:
- 单细胞RNA测序 (scRNA-seq) 的男性T. dalmanni. 性腺.
- 构建男性生殖腺单细胞地图.
- 驱动和标准丸之间的基因表达的比较分析.
主要成果:
- 识别了主要的丸细胞类型,并描述了转录格局.
- 观察到不完全的介质性性别染色体不活化和复杂的剂量补偿.
- 发现介质驱动因素不会破坏基本的X链基因调节模式.
- 突出显示的基因表达变化,可能是由于精子生成中断.
结论:
- 在T. dalmanni中,精子驱动对精子生成和性染色体调节有特定的影响.
- 该研究提供了关于介质驱动器如何偏向自身传输的见解.
- 鉴定了受 meiotic 驱动影响的候选基因,为未来的研究提供了途径.
相关概念视频
The Ratio of X Chromosome to Autosomes
9.4K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
9.4K
Dosage Compensation
7.0K
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
7.0K
Meiosis II
49.1K
Meiosis II entails cell division and segregation of the sister chromatids, resulting in the production of four unique haploid gametes. The steps for meiosis II are similar to mitosis, except that meiosis II occurs in haploid cells, whereas mitosis occurs in diploid cells.
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...
49.1K
Meiosis II
207.1K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
207.1K
Meiosis vs. Mitosis
69.4K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
69.4K
Meiosis I
43.8K
Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
43.8K


