介质素-1β抑制了老鼠嗅觉球中的神经元活动,即使在气味刺激期间也是如此
Adriana Jiménez1, Josué Denichi Sánchez-Hernández2,3, Viani Maya-López3
1División de Investigación, Hospital Juárez de México, Gustavo A. Madero, Ciudad de México, México.
PloS one
|September 18, 2025
概括
介质素-1β (IL-1β) 通过减少嗅球和内腔皮层中神经元活动,可能导致嗅觉功能障碍. 阻断IL-1β部分恢复了嗅觉唤起的潜能,这表明在嗅觉障碍中发挥了作用.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 嗅觉系统研究 嗅觉系统研究
背景情况:
- 嗅觉系统易受外部和内部有害物质的影响,导致神经通信受损.
- 炎症分子,如介素-1β (IL-1β),在感染和全身疾病期间在嗅觉系统中增加.
- 以前的研究将糖尿病大鼠的嗅球 (OB) 中IL-1β的增加与嗅功能障碍联系起来.
研究的目的:
- 调查IL-1β是否对嗅觉障碍负责.
- 评估IL-1β及其对抗体IL-1Ra在老鼠嗅球 (OB) 和内腔皮层 (EC) 的电生理作用.
主要方法:
- 微注射IL-1β和IL-1受体对抗剂 (IL-1Ra) 进入大鼠的OB.
- 在休息和刺激条件下在OB和EC中记录局部场势 (LFP).
- 对动物的IL-1β受体1 (IL1-R1) 表达的RNA-seq数据的分析.
主要成果:
- IL-1β降低了OB的总光谱功率,增加了OB和EC的信号频率和马功率.
- IL-1β降低了嗅觉唤起潜能 (OEP) 幅度和延迟的增加.
- IL-1Ra部分挽救了OEP振幅和延迟,但对IL-1β引起的光谱功率变化的影响较小.
结论:
- 通过抑制OB和EC中的神经元活动,IL-1β可能会诱导嗅觉功能障碍.
- IL-1β可能在嗅觉系统中起着生理作用,因为IL-1Ra调节了这些大脑区域的电活动.
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