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Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
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核受体核心调节器NRIP1 R448G调节T细胞肠道导向以控制肠道炎症

Xiangjun Chen1,2,3, Hee Seung Hwang2, Bihua Li2

  • 1Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.

Proceedings of the National Academy of Sciences of the United States of America
|September 18, 2025
PubMed
概括

一种核受体相互作用蛋白1 (NRIP1) 风险变体通过促进CD4+ T细胞归宿而加剧肠道炎症. 该研究揭示了NRIP1的存在.

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