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相关概念视频

Gastrulation01:56

Gastrulation

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Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
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Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Cell Migration01:09

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Morphogenesis02:19

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Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
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Mechanism of Lamellipodia Formation01:31

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Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
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Cell Motility through Blebbing01:16

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Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
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相关实验视频

Updated: Jan 17, 2026

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix
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Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

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一个边界驱动的组织形态发生的模型.

Daniel S Alber1,2, Shiheng Zhao3,4,5, Alexandre O Jacinto6

  • 1Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08540.

Proceedings of the National Academy of Sciences of the United States of America
|September 18, 2025
PubMed
概括
此摘要是机器生成的。

发育过程中的组织变形可能是被动的. 这项研究使用Drosophila后肠来展示边界力通过机械过程驱动复杂的形状变化,比如三角形钥匙孔.

关键词:
多虫的发展发展.机械分支的机械分支形态发生 (morphogenesis) 是一种形态的产生.组织力学组织力学

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Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo
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相关实验视频

Last Updated: Jan 17, 2026

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix
08:49

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

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Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo
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Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

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科学领域:

  • 发育生物学 发展生物学
  • 生物物理学的生物物理.
  • 形态发生 形态发生 形态发生

背景情况:

  • 形态发生过程中的组织变形是由内部活跃过程或外部被动边界应力驱动的.
  • 德洛索菲拉后肠原始提供了一个模型来研究边界驱动的组织形态发生.

研究的目的:

  • 为了表征Drosophila hindgut primordium的3D变形. 为了表征Drosophila hindgut primordium的3D变形.
  • 为了确定复杂的后肠形状变化是否是由被动边界力造成的.
  • 为了建模这些变形的机械基础.

主要方法:

  • 在Drosophila hindgut.gut.中3D组织变形的表征.
  • 在圆形表面上构建最小弹性环模型.
  • 使用轮分析量化组织动力学.
  • 在边界条件下的被动变形的建模.

主要成果:

  • 在3D变形过程中,Drosophila后肠表现出中间的"三角钥匙孔"形状.
  • 一个极小的模型强大地捕捉了这种破坏对称性的形状变化.
  • 后肠变形发生在两个阶段:表面转换和快速形状对称性破坏.
  • 观察到的动力学与被动变形模型是一致的.

结论:

  • 复杂的后肠形态发生可能是周围活跃胚胎组织变形的被动后果.
  • 统一的边界条件足以产生不统一的形状变化.
  • 这种被动机制为理解胚芽孔等价形状和发育过程中的全球形态提供了一个框架.