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食物敏感性与阿托皮性皮肤炎的严重程度,肠道衍生代谢物和成人肠道泄漏有关
Leszek Blicharz1, Emilia Samborowska2, Radosław Zagożdżon3
1Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
Clinical and translational allergy
|September 18, 2025
概括
食物敏感性在患有亚托邦性皮肤炎的成年人中更为常见,并且与疾病严重程度有关. 肠道微生物组的变化和泄漏的肠道生物标志物可能起到作用,这表明饮食干预措施可用于治疗亚托皮炎.
科学领域:
- 皮肤病学 皮肤病学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物组失调与代谢问题和肠道屏障受损有关.
- 肠道屏障受损的假设是引发食物过敏并加剧皮肤炎症.
- 这项研究研究了成人亚托皮性皮炎患者的食物敏感性及其与疾病严重程度和肠-皮肤轴生物标志物的关系.
研究的目的:
- 为了确定成年亚托皮性皮肤炎患者中食物敏感化的患病率.
- 为了将食物敏感性与阿托皮性皮肤炎的严重程度相关联 (SCORAD,EASI分数).
- 检查食物敏感性,疾病严重程度和肠-皮肤轴生物标志物之间的关系.
主要方法:
- 对50名成年阿托皮性皮肤炎患者和25名对照者的横截面研究.
- 使用SCORAD和EASI分数评估疾病严重程度.
- 通过LC-MS,Luminex和Polycheck测定,分析血清生物标记物,包括总IgE,食品特异性IgE,肠道代谢物和漏肠标记物.
主要成果:
- 与对照组相比,亚托皮性皮肤炎患者的食物敏感性明显更高.
- 亚托匹性皮肤炎的严重程度与食物敏感性和食物特异性IgE的数量相关.
- 较高的IgE水平和食物敏感性与较低的短链脂肪酸和较高的氧和漏肠生物标志物有关.
结论:
- 食物敏感化和亚托皮性皮肤炎严重程度之间存在联系,可能由肠道代谢物和肠道屏障功能障碍介导.
- 饮食干预措施,如增加纤维和限制蛋白质,可以调节肠道代谢物 (例如,SCFA,induxyl) 以减少在亚托皮炎中食物敏感化风险.
- 需要进一步的前性研究来确定因果关系,因为这项研究的探索性,横截面性质.
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