问卷和加速仪测量身体活动,遗传易感性和慢性肝病风险
Yingxin Liao1, Xinping Yan2, Jingye Tai2
1Department of Nutrition, School of Public Health, Guangzhou Medical University, Guangzhou, China.
概括
增加体力活动 (PA),特别是中度至强烈强度的PA (MVPA),显著降低慢性肝病 (CLD) 的风险. 达到更高的中等强度PA (MPA) 量是有益的,特别是对具有遗传易感性的个体.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 运动科学 运动科学
背景情况:
- 以前关于体力活动 (PA) 和慢性肝病 (CLD) 的研究经常使用主观数据,忽视了遗传因素.
- 了解各种PA参数与CLD风险之间的细微关系对于预防策略至关重要.
研究的目的:
- 综合研究不同类别,体积,强度和PA的模式与CLD风险之间的联系.
- 调查遗传敏感性在PA-CLD关系中的作用.
主要方法:
- 使用了两项大型队列研究,一项采用问卷测量PA (335,522名参与者),另一项采用加速度计测量PA (80,659名参与者).
- 事件CLD和肝脏相关事件 (LRE) 使用链接的医院和死亡记录进行了跟踪.
- 考克斯的比例危险回归模型被用来分析这些关联.
主要成果:
- 休活动,家务和休骑自行车显示与CLD和LRE的反向关联.
- 较高的总PA体积,特别是中度至强度的PA (MVPA),与降低的CLD/LRE风险相关,不论遗传倾向如何.
- 观察到与中等强度PA (MPA) 和强烈强度PA (VPA) 结合的最佳风险降低,在加速仪测量PA和遗传风险之间发现了显著的相互作用.
结论:
- 建议增加总PA,重点关注MVPA,以预防肝脏疾病.
- 在日常生活中达到更高水平的MPA提供了显著的好处,特别是对于具有高遗传风险的个人来说.
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