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Updated: Jan 17, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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在KEAP1突变肺癌中,UXS1的丧失会选择性地降低皮里米丁,并诱导复制压力

Melat T Gebru1, Timothy E Hoffman1, Aaron Boudreau1

  • 1Calico Life Sciences LLC, South San Francisco, California.

Cancer research
|September 18, 2025
PubMed
概括

KEAP1突变癌症依赖于UDP-酶合成酶1 (UXS1). 抑制UXS1导致DNA复制压力,为非小细胞肺癌提供了一种新的治疗策略. 这突出了UXS1作为潜在的药物目标.

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