2年以上儿童多发性硬化症患者的认知功能
Kimberly A O'Neill1, Leigh Charvet1, Michael Waltz2
1Department of Neurology, NYU Grossman School of Medicine, New York.
Neurology
|September 18, 2025
概括
大多数患有儿科多发性硬化症 (MS) 的儿童在两年内保持了稳定的认知功能,类似于健康的同龄人. 然而,一个小组的处理速度有所下降,这凸显了儿童多发性硬化症患者认知健康监测的必要性.
科学领域:
- 神经学 神经学
- 儿科 儿科 儿科
- 认知科学 认知科学
背景情况:
- 儿童多发性硬化症 (MS) 影响儿童的神经和认知发育.
- 儿童多发性硬化症认知功能的长度研究有限.
- 认知障碍是儿童多发性硬化症的一个已知的问题.
研究的目的:
- 纵向评估两个多年多发性硬化症儿童的认知功能.
- 为了比较儿科MS患者的认知变化与年龄相匹配的健康对照 (HCs).
- 为了研究儿童MS的认知变化,与早期发病的MS的成年人相比.
主要方法:
- 在七个美国地区招募了三个队列:儿科MS,儿科HC和成人MS患者.
- 在基线和随访时使用Cogstate简要电池 (CBB) 和MS国际简要认知评估 (BICAMS).
- 分析了复合z-score和个体认知指标的变化,计算可靠的变化指数 (RCI).
主要成果:
- 儿科MS和儿科HC之间CBB复合z-score变化没有显著差异 (p=0.113).
- 儿童多发性硬化和成人多发性硬化组也显示出类似的认知变化 (p=0.987).
- 虽然80%的儿科MS患者情况稳定或有所改善,但19.7%的认知能力下降,而对照组5.1% (p=0.022).
结论:
- 大多数儿科MS患者在两年内表现出稳定的认知功能.
- 儿科MS的认知变化在很大程度上与健康儿科对照组的认知变化相当.
- 儿科MS患者的一个子集可能会随着时间的推移而经历认知处理速度的下降.
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