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Updated: Jan 17, 2026

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HDAC1表面的突变揭示了特定复杂组合的分子决定因素及其对基因调节的要求

Ahmad Alshehri1, India-May Baker1, David M English1

  • 1Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, UK.

Nucleic acids research
|September 18, 2025
PubMed
概括

基因脱乙酶1和2 (HDAC1/2) 是基因调节的关键. 一个特定的突变 (Y48E) 表明,仅与SIN3复合体的结合对细胞存活至关重要,影响基因表达.

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