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Updated: Jan 17, 2026

Deciphering Molecular Mechanism of Histone Assembly by DNA Curtain Technique
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解读表观遗传UHRF1蛋白质SET和RING相关 (SRA) 域的基翻转机制

Dipanjan Mukherjee1, Stefano Ciaco1,2, Lara Martinez-Fernandez3

  • 1Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS Université de Strasbourg, Faculté de pharmacie, 74 route du Rhin, Illkirch 67401, France.

Nucleic acids research
|September 18, 2025
PubMed
概括

含有PHD和RING手指域1 (UHRF1) 的乌比奎丁类,使用基点翻转来区分5-甲基细胞因 (5mC) 和细胞因. 这一过程对于DNA甲基化复制和DNA甲基转移酶1 (DNMT1) 的招募至关重要.

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