在患有IgG4相关疾病的患者中,脑下神经扩大
Ryoshin Mizuno1,2, Yuhei Ito1,2, Rufuto Ando1,2
1Department of Rheumatology, Centre for Rheumatic Diseases, Mie University Hospital, Tsu, Mie, Japan.
Modern rheumatology case reports
|September 18, 2025
概括
这项案例研究强调了阴道下神经扩大 (IONE) 作为IgG4相关疾病 (IgG4-RD) 的罕见表现. 早期诊断和治疗至关重要,尽管IONE可能无法通过标准疗法完全治愈.
科学领域:
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學.
- 眼科医生 眼科 眼科
背景情况:
- 与IgG4相关的疾病 (IgG4-RD) 是一种全身性纤维炎症性疾病.
- 虽然通常会影响唾液和眼腺,但IgG4-RD可以涉及其他组织,包括低轨道神经扩大 (IONE),这并未得到广泛认可.
研究的目的:
- 报告IgG4相关疾病 (IgG4-RD) 病例与临床显著的阴道下神经扩大 (IONE).
- 讨论IONE在IgG4-RD.背景下的诊断挑战和管理考虑.
主要方法:
- 一名54岁的妇女呈现出紫外线,阴,肌水平升高,高血糖球蛋白血症和显著升高的血清IgG4水平.
- 调查包括CT扫描显示轨道外骨结构和脏活检显示IgG4阳性血细胞透与管介质炎一致.
- 这名患者被诊断出患有IONE并发症的IgG4-RD,并患有管间炎.
主要成果:
- 这名患者的血清IgG4水平升高 (2924 mg/dl),患有乳酸蛋白和功能障碍.
- CT成像显示了双边的轨道下骨像道的结构.
- 脏活检证实了IgG4相关的管介质炎. 用葡萄糖皮质类药物和修复剂治疗改善了功能,但没有IONE.
结论:
- 脑下神经扩大 (IONE) 是IgG4相关疾病 (IgG4-RD) 的一个未被认可的表现.
- 诊断需要高度的怀疑指数和全面的调查,包括血清学和成像学研究.
- 虽然治疗可以改善系统性表现,但IONE可能对标准疗法具有耐药性,因此需要进一步研究最佳管理策略.
关键词:
与IgG4相关的疾病案例报告案例报告计算机断层扫描 (CT) 是一种计算机断层扫描.阴道下神经扩大 阴道下神经扩大磁共振成像技术的使用轨道参与 轨道参与这就是Rituximab.三角神经是三角神经的一部分.管腔间歇性炎 管腔间歇性炎更多相关视频
08:04A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies
Published on: January 24, 2020
13.0K
05:38Author Spotlight: Utilizing Infraorbital Nerve Ligation in Mice for Investigating Trigeminal Neuropathic Pain and Treatment Strategies
Published on: March 8, 2024
2.8K
相关概念视频
01:17Accessory Structures of the Eye
3.4K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
3.4K
01:25Glaucoma: Overview
1.3K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.3K
01:20Muscles of the Eye
3.9K
The muscles of the eye are sophisticated structures that control eye movement and focus, allowing for the precise and rapid adjustments necessary for vision. The human eye is controlled by ten muscles — six extraocular muscles, three intraocular muscles, and one primary eyelid retractor muscle.
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and...
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and...
3.9K