女性和男性患有小腹主动脉动脉瘤的比较
Heather Ngai1, Sydney Olson2, John Curci3
1Department of Emergency Medicine, Harbor-University of California Los Angeles, Los Angeles, California, USA.
The British journal of surgery
|September 18, 2025
概括
患有小腹主动脉动脉瘤 (AAA) 的女性比男性更快地经历动脉瘤生长. 这项研究强调了AAA进展和患者病史中与性别相关的关键差异.
科学领域:
- 血管外科 血管外科
- 心血管研究研究心血管研究
- 医学统计 医学统计
背景情况:
- 腹腔大动脉瘤 (AAA) 呈现出与性别相关的差异,影响患者的护理和研究.
- 在美国,女性被诊断为AAA的频率低于男性.
- 腹腔大动脉动脉瘤非侵入性治疗临床试验 (N-TA3CT) 为探索这些差异提供了数据.
研究的目的:
- 调查患者特征,动脉瘤生长率和临床结果的性别相关差异.
- 分析N-TA3CT数据,以比较具有小AAA的男性和女性.
- 为了确定AAA管理和性别之间进展的潜在差异.
主要方法:
- 使用N-TA3CT (NCT01756833) 的二次数据分析进行的回顾性队列研究.
- 包括166名基线AAA直径≤4.5厘米和随访CT扫描的参与者.
- 在男性和女性参与者之间比较了患者人口统计,动脉瘤生长,不良事件和结果.
主要成果:
- 在研究队列中,女性占21.1% (35),男性占78.9% (131).
- 女性报告的AAA家族病史发生率较高 (31.4%对16.0%,P=0.05).
- 女性的AAA年增长率显著更快 (0.21厘米/年对0.16厘米/年,P<0.001),并且不太可能服用他类药物或抗血小板药物.
结论:
- 小腹部大动脉动脉瘤 (3.5-4.5厘米) 显示女性的增长速度比男性更快.
- 女性报告的AAA家族病史更频繁.
- 这些发现强调了需要在AAA研究和临床实践中考虑性别特异性的必要性.
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