认知障碍与对非小细胞肺癌瘤驱动器阳性患者的第一线向治疗之间的关系:前性队列研究
Wenjun Chen1, Xueyang Hu2, Senbang Yao3
1Department of Oncology, Phase I Clinical Center, Anhui Chest Hospital, Hefei, China.
JMIR cancer
|September 18, 2025
概括
接受向治疗的晚期肺癌患者的认知障碍与较差的生存率和生活质量有关. 早期查认知变化对于改善患者的治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 以前的研究表明,认知障碍和化疗之间存在联系.
- 由于基因测试,有针对性的疗法越来越多地被使用,但它们对认知功能的影响尚不清楚.
研究的目的:
- 研究针对性治疗对晚期肺癌患者认知功能的影响.
- 探索认知功能,C-反应蛋白和心理压力之间的关联.
主要方法:
- 选择了87名具有基因突变的高级非小细胞肺癌 (NSCLC) 患者.
- 评估包括迷你精神状态检查,苦难温度计和EORTC QLQ-C30.
主要成果:
- 患有认知障碍的患者的无进展生存率 (PFS) 和反应率显著降低.
- 在受影响和未受影响组中,治疗后认知功能下降.
- 治疗后,生活质量和C-反应蛋白水平显示出显著的差异和趋势.
结论:
- 认知障碍与接受向治疗的患者的生活质量和PFS降低有关.
- 对认知障碍的早期查和干预可以改善临床结果和患者的福祉.
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