相关实验视频
Updated: Jan 17, 2026

06:08
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
24.2K
皮质醇测试以诊断上腺功能衰竭在上腺切除术后的轻度自主皮质醇分泌
Oksana Hamidi1, Bahaa Salama2, Tracy Wang3
1Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, TX.
The Journal of clinical endocrinology and metabolism
|September 18, 2025
概括
手术后的上腺功能衰竭影响了超过一半的手术后轻度自主皮质醇分泌 (MACS) 的患者. 恢复平均3.9个月,但由于结果不一致,建议测试基底皮质醇和共热激素刺激测试 (CST).
科学领域:
- 内分泌学 在内分泌学.
- 外科手术的结果
背景情况:
- 患有轻度自主皮质醇分泌 (MACS) 的患者在单方面上腺切除术后面临上腺功能衰竭的风险.
- 上腺功能不充分可以显著影响患者的康复和术后的长期健康状况.
研究的目的:
- 确定MACS单边上腺切除术后患者上腺功能不全的患病率,持续时间和预测因素.
- 为了比较手术后的基本皮质醇水平和共热激素刺激试验 (CST) 的诊断效用.
主要方法:
- 一项多中心回顾性研究,涉及281名患有MACS的患者.
- 使用基底皮质醇 (<10μg/dL) 和CST (<18μg/dL) 的特定切断值来诊断上腺功能不充分.
- 生物化学 (BSS) 和临床 (CSS) 严重程度得分被计算出来,以评估疾病的严重程度和恢复.
主要成果:
- 超过一半 (54.5%) 的患者患上了术后上腺功能衰竭,与年龄相反相关.
- 基底皮质醇和CST结果在22%的病例中不一致,特别是在双边结节患者中.
- 上腺功能衰竭的中位恢复时间为3.9个月,较长的持续时间与更高的BSS和CSS有关.
结论:
- 在MACS患者单侧上腺切除术后,上腺功能不充分是常见的,中位恢复时间约为3.9个月.
- 生物化学严重性得分与上腺功能衰竭的持续时间相关.
- 由于在诊断结果中观察到的不一致性,建议在术后执行基底皮质醇和CST.
相关概念视频
Adrenal Gland Disorders
2.9K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
2.9K
Hormones of the Adrenal Glands
4.6K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
4.6K
Hypothalamic-Pituitary Axis
65.5K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
65.5K
Anatomy of the Adrenal Glands
4.3K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
4.3K
Hypoglycemia and Glucagon
838
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
838
Physiological Foundation of Stress
580
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
580

