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Updated: May 7, 2026

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
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PU.1恢复由C9ORF72重复扩张引起的微质功能障碍神经器官中的神经器官

Tijana Ljubikj1, Mayte Z Mars1, Astrid T van der Geest1

  • 1Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, 3584 CG, Utrecht, The Netherlands.

Brain : a journal of neurology
|September 18, 2025
PubMed
概括

由于C9ORF72的重复扩张,肌缩性侧面硬化症 (ALS) 和前性痴呆症 (FTD) 的微质功能受损. 恢复转录因子PU.1可以拯救这些微质缺陷,为C9-ALS/FTD提供潜在的治疗点.

关键词:
C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C骨髓缩侧面硬化症 (ALS) 是一种微质细胞中的微质细胞神经器官有机体 神经器官有机体发酵细胞的形成 发酵细胞的形成突触突触是指突触中的突触.

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