相关实验视频

Updated: Jan 17, 2026

A Novel Method: Super-selective Adrenal Venous Sampling

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

在一次性上腺功能衰竭中增加的死亡率:系统性审查和元分析

Konstantinos Dalakas^1,2, Francesca Allosso³, Christian Basile^4,5

¹Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

European journal of endocrinology

|September 18, 2025

概括

患有原发性上腺功能衰竭 (PAI) 的患者面临显著增加的死亡风险,大约是普通人群的2.5倍. 心血管疾病是PAI患者的主要死亡原因.

科学领域:

内分泌学在内分泌学.
内部医学内部医学
公共卫生公共卫生

背景情况:

主要上腺功能缺陷 (PAI) 管理已取得进展,但患者的预后仍然很差.
现有的关于PAI死亡率的数据不一致,需要进行全面的综合分析.
先天性上腺增生 (CAH) 是PAI死亡率研究中的一个关键考虑因素.

研究的目的:

系统地审查和分析成人PAI患者死亡率的证据.
综合现有关于PAI中死亡率的数据,包括那些患有CAH的人.
提供对PAI患者预后的综合了解.

主要方法:

观察性研究的系统审查和元分析.
在Medline,Cochrane CENTRAL,Web of Science和Embase数据库中搜索相关文献.
包括将PAI患者的死亡率与参考人群进行比较的研究,经过严格的查和全文审查.

主要成果:

确定了涉及13,969名患者的9份报告;7项研究 (9,876名患者) 纳入了元分析.
聚合危险比 (HR) 为2.51 (95% CI为1.47-4.31),表明死亡风险增加了2.5倍.
汇集的标准化死亡率 (SMR) 为2.49 (95% CI 0.99-6.28). 心血管疾病是死亡的主要原因.
对CAH患者的子分析显示,合并HR为2.88 (95%CI为1.38-6.01),上腺危机是死亡的主要原因.

结论:

患有PAI的患者的死亡率显著增加,大约是参考人群的2.5倍.
心血管疾病是PAI一般人群中的主要死亡原因.
上腺危机被确定为主要死亡原因,特别是在CAH的PAI患者中.

关键词:

出生性上腺增生症.这是一个元分析.死亡率死亡率原发性上腺功能衰竭系统性审查系统性审查

更多相关视频

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

相关概念视频

Adrenal Gland Disorders

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...

Hormones of the Adrenal Glands

Hormones of the Adrenal Glands

Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...

Anatomy of the Adrenal Glands

Anatomy of the Adrenal Glands

The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...

Hypoglycemia and Glucagon

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...

Heart Failure II: Pathophysiology

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...