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吸烟对ocrelizumab治疗多发性硬化症患者的临床结果的影响
Nada Said1, Hoang Nhat Pham2, Mahmoud Abdelnabi1
1Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ, USA.
Multiple sclerosis and related disorders
|September 18, 2025
概括
吸烟显著恶化了多发性硬化症 (MS) 患者接受ocrelizumab治疗的结果,增加了神经事件,住院和死亡的风险. 戒烟对于管理多发性硬化症至关重要,即使使用先进疗法.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 吸烟是多发性硬化症 (MS) 进展的已知危险因素.
- 吸烟对现代疾病修饰疗法ocrelizumab对MS结局的影响尚不清楚.
研究的目的:
- 调查使用ocrelizumab治疗的MS患者的吸烟和临床结果之间的关联.
- 评估吸烟对神经事件,住院和死亡率的影响.
主要方法:
- 基于索赔的回顾性队列研究,使用TriNetX研究网络.
- 用ocrelizumab治疗的成年多发性硬化患者被纳入并按吸烟状况分层.
- 倾向性得分匹配用于控制混因素,Cox比例危险模型分析结果.
主要成果:
- 与非吸烟者相比,接受ocrelizumab的吸烟者表现出类似的视神经炎,但与非吸烟者相比,四肢疲软,发作,尿失禁和抑郁症的风险明显更高.
- 吸烟组的全因住院和死亡率也明显高于吸烟组.
- 该研究包括5998名患者,平均年龄为45.0岁,60%为女性.
结论:
- 吸烟与接受ocrelizumab的MS患者的神经和整体结果明显恶化有关.
- 这些发现强调了戒烟作为MS管理中可修改的风险因素的关键重要性.
- 解决吸烟问题对于优化护理至关重要,即使对于像ocrelizumab这样的先进免疫疗法患者也是如此.
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