米的真菌耐药性通过进化上丢失的共同受体的家族间转移而恢复
Qian Zhang1, Wenyue Zheng1, Haoxiang Huang2
1Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.
Cell host & microbe
|September 18, 2025
概括
转移植物免疫受体 (PRRs) 可以增强作物免疫力. 一种真菌MAMP,STOM,在一种植物中引发免疫力,但在另一个植物中由于单种植物的共同受体损失而不会引发免疫力,提供了一种提高作物抗病能力的策略.
科学领域:
- 植物免疫力 植物免疫力
- 分子植物病原体相互作用
- 农作物科学 农作物科学
背景情况:
- 模式识别受体 (PRR) 的家族间转移是一种增强植物免疫力的策略.
- 跨物种的PRR的功能限制阻碍了它们的应用.
- 了解这些局限性对于提高作物抗病能力至关重要.
研究的目的:
- 确定限制PRRs家族间转移的因素.
- 描述一种新型的真菌微生物关联分子模式 (MAMP) 和它的受体.
- 制定策略来克服植物免疫的分类学障碍.
主要方法:
- 鉴定和描述一种新型真菌MAMP (STOM)及其受体 (NbSTOMR) 和Nicotiana benthamiana中的共受体 (NbSTOMRh).
- 在N. benthamiana和Oryza sativa (大米) 中对STOM,NbSTOMR和NbSTOMRh的功能分析.
- 在单和双中对STOMR和STOMRh基因的进化分析.
主要成果:
- 一种真菌MAMP,分泌TOM20域含蛋白 (STOM),触发了N. benthamiana的免疫力,但不是大米.
- NbSTOMR识别了STOM,而NbSTOMRh则充当了一个重要的共同受体.
- 单独NbSTOMRh可以增强大米对真菌病的抵抗力,并促进大米PRRs.通过STOM识别.
- 由于转子子活性而导致的STOMRh的单细胞损失,解释了STOM触发免疫力的失败.
结论:
- 同受体在克服PRR功能的分类学障碍方面发挥着至关重要的作用.
- 重建功能性共受体可以恢复作物中PRR介导的免疫力.
- 这项研究提供了一种增强单种作物对真菌病原体免疫力的策略.
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