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用喷墨打印的药物装载的临时纹身,用于个性化的儿科疼痛治疗
Simone Eder1, Matthias Wolfgang1, Manuel Zettl1
1Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria.
International journal of pharmaceutics
|September 18, 2025
概括
装有药物的临时纹身提供了一种新的,儿童友好的药物管理方式. 这种个性化的方法使用装饰性纹身来改善儿科治疗的坚持和接受.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 儿童的药物坚持是家长面临的重大挑战,因为儿童拒绝传统的剂量形式.
- 现有的局部输送方法,如奶油和贴片,对儿童来说可能是不方便或痛苦的.
- 儿童对装饰性临时纹身的吸引力为创新的药物输送提供了机会.
研究的目的:
- 开发一种新的小儿用药剂型,利用含有药物的临时纹身.
- 为儿童创建个性化和有吸引力的药物输送系统.
- 证明使用增材制造来控制药物装载和输送的可行性.
主要方法:
- 开发一种原型纹身治疗疼痛使用利多卡因/普里洛卡因欧特基混合物.
- 压电喷墨印刷的应用,将药物沉积在装饰性图案上.
- 使用近红外高光谱成像用于药物含量的非破坏性量化.
- 使用人类皮肤评估药物输送的ex-vivo透研究.
主要成果:
- 对于使用近红外高光谱成像的0至25毫克厘米2的药物剂量建立了线性相关模型 (R2 0.9925).
- 装有毒品的纹身显示易于应用,在30分钟内有效地透到人体皮肤中的活体药物.
- 在皮肤上部检测出0.69和0.78μg·g-1的利多卡因和普罗卡因度.
结论:
- 含有药物的临时纹身代表了儿童治疗的可控和高度可接受的替代方案.
- 低成本的增材制造,特别是压电喷墨印刷,可以定制药物内容.
- 这种创新的剂型解决了儿科药物坚持和接受方面的挑战.
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