评估tDCS在减少精神分裂症谱系障碍的负面症状中的有效性:系统性审查和元分析
Raquel Guiomar1, Monica Sobral2, Lieze Vanden Berghe3
1University of Coimbra (Portugal), Center for Research in Neuropsychology and Cognitive and Behavioral Intervention (CINEICC), Faculty of Psychology and Educational Sciences, Coimbra, Portugal.
Brain stimulation
|September 18, 2025
概括
跨直流刺激 (tDCS) 在减少精神分裂症谱系障碍 (SSD) 的负面症状方面提供了适度的好处. 这种附加疗法在针对负面症状时最有效,特别是在左侧脊侧前额叶皮层刺激时.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗器械 医疗器械
背景情况:
- 精神分裂症谱系障碍 (SSD) 的负面症状显著损害了功能和生活质量.
- 目前针对负面症状的治疗方法的有效性有限.
- 跨直流刺激 (tDCS) 正在作为辅助疗法进行探索,但结果不一致.
研究的目的:
- 进行元分析,评估tDCS在减少SSD负面症状方面的有效性.
- 通过子组和调节分析来确定影响tDCS疗效的因素.
主要方法:
- 随机对照试验的系统综述和元分析,比较SSD患者的活性tDCS与虚假tDCS.
- 计算标准化平均差异 (SMD) 以量化治疗效果.
- 通过子组和调节分析探索异质性.
主要成果:
- 与假刺激 (中等异质性) 相比,tDCS显示了负面症状的显著减少.
- 在仅关注精神分裂症和负面症状是主要目标的研究中观察到更大的疗效 (SMD = -0.80).
- 左背侧前额皮层 (lDLPFC) 的刺激与症状减少有关 (SMD = -0.30);在随访时没有持续的效果.
- 发现tDCS是安全的,并且耐受性良好.
结论:
- tDCS显示出作为SSD中负面症状的附加治疗方法的适度但显著的效果,特别是当协议针对这些症状并利用DLPFC刺激时.
- 需要进一步的研究来研究长期疗效和个性化治疗方法.
- 维护会议可能需要维持治疗效益.
相关概念视频
Negative and Cognitive Symptoms of Schizophrenia
470
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
470
Drug Therapy
245
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
245
Psychosis: Goals of Pharmacotherapy
476
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
476
Electroconvulsive Therapy
916
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
916
Therapeutic Drug Monitoring: Affecting Factors
202
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
202
Psychosis and Antipsychotic Drugs: Overview
817
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
817


