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肠肝轴:肥胖管理中的炼新兴目标

Laura Alexia Ramos-da-Silva¹, Henrique Souza-Tavares¹, Gabriela Rodrigues Medeiros¹

¹Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, Anatomy Department, Rio de Janeiro State University, Rio de Janeiro 20551030, Brazil.

Clinics and research in hepatology and gastroenterology

|September 18, 2025

概括

身体炼,包括中等强度持续训练 (MICT) 和高强度间歇训练 (HIIT),可以改善肠道屏障功能,并减轻肥胖模型中与代谢功能障碍相关的脂肪性肝病 (MASLD). 对于肠道健康和MASLD缓解,HIIT特别有前途.

科学领域:

代谢障碍代谢障碍代谢障碍
肠 - 肝轴研究研究
运动生理学运动生理学

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 与肠道失调和内毒性有关.
肥胖加剧了MASLD,治疗选择有限.
在MASLD中,运动强度对肠肝轴的影响尚未完全理解.

研究的目的:

审查中等强度持续训练 (MICT) 和高强度间歇训练 (HIIT) 在实验肥胖模型中如何调节肠肝轴.
研究运动对肠道屏障功能的影响和肝脏平衡 (线粒体和内分泌网膜).

主要方法:

在实验肥胖模型中对运动干预 (MICT和HIIT) 的研究进行了全面的文献综述.
专注于肠道透性,紧的结节,内毒性,肝脏内等质网膜 (ER) 和线粒体功能.

主要成果:

无论是MICT还是HIIT,都通过恢复紧密的结节和减少肠道透性来改善肠道屏障的完整性.
运动通过减少内毒性,通过改善ER和线粒体平衡,抵消葡萄糖脂毒性和炎症来缓解MASLD.
与MICT相比,HIIT在增强肠道结构,微生物群多样性,减少脂肪和改善胰岛素敏感性方面表现出优异的效果.

结论:

运动,特别是HIIT,是通过向肠肝轴来管理MASLD的一个有希望的非药物战略.
通过定期运动调节肠肝轴对于打击肥胖大流行和相关肝病至关重要.

关键词:

肠 - 肝轴肠 - 肝轴高强度间歇训练高强度间歇训练线粒体中的线粒体.适度强度的持续训练中等强度的持续训练肥胖问题肥胖问题

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