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与糖尿病黄斑瘤中的光学连贯性断层扫描生物标志物相关的视觉结果:系统性审查

Keean Nanji¹, Amin Hatamnejad², Justin Grad²

¹McMaster University, Department of Surgery, Department of Surgery, Division of Ophthalmology, 2757 King Street East, Hamilton, Ontario, Canada; McMaster University, Department of Health Research Methods, Evidence and Impact, 1280 Main Street West, Hamilton, Ontario, Canada.

Survey of ophthalmology

|September 18, 2025

概括

基线光学连贯性断层扫描 (OCT) 生物标志物不能可靠地预测视力敏度 (VA) 对糖尿病黄斑 (DME) 治疗的反应. 一些海外国家和地区的发现表明VA更糟糕,但证据确定性较低,限制了预测价值.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
视网膜疾病视网膜疾病

背景情况:

糖尿病黄斑 (DME) 是导致视力丧失的主要原因.
有效的治疗反应预测对于管理DME至关重要.
光学连贯断层扫描 (OCT) 提供了对视网膜变化的结构洞察.

研究的目的:

评估基线OCT生物标志物对DME患者功能治疗反应的预测价值.
评估在治疗后6,12和24个月的OCT生物标志物和视力敏度 (VA) 之间的关联.

主要方法:

96项研究的系统审查和投票计数综合.
在Ovid MEDLINE,EMBASE和Web of Science中搜索了关于DME的OCT生物标志物和VA的基线研究.
用于评估证据确定性的GRADE准则.

主要成果:

没有任何基线CT国外生物标志物可靠地预测了至少"低"确定性改善VA.
大圆形区域 (EZ) 干扰和高反射焦点与6个月的VA降低有关 (确定性低).
视网膜内层的失调和外部边界膜/EZ破坏与12个月的VA降低有关 (低确定性).

结论:

基线的OCT生物标志物在预测对DME抗VEGF,类固醇或激光治疗视力敏度反应的价值有限.
证据的确定性低,混和缺乏标准化阻碍了生物标志物的实用性.
需要使用标准化方法进行进一步的研究,以确定可靠的预测生物标志物.

关键词:

抗-VEGFF是一种抗生素.生物标志物生物标志物糖尿病糖尿病糖尿病糖尿病性黄斑胀糖尿病性黄斑胀糖尿病视网膜病变 - 糖尿病视网膜病变海洋生物标志物海洋生物标志物个性化治疗个性化治疗系统性审查系统性审查

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