在CKD中准炎症
Kristen L Nowak1, Michel Chonchol1
1Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
概括
针对慢性炎症途径显示出减缓病进展和降低慢性病患者心血管疾病风险的前景. 目前正在进行的试验正在研究抗细胞因子治疗等疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
背景情况:
- 由天生的免疫激活驱动的慢性系统性炎症显著导致慢性病 (CKD) 和其并发症,包括动脉样硬化和心血管疾病 (CVD).
- 向炎症途径代表了过去15年来研究的新型治疗策略,旨在减轻CKD患者的心血管疾病风险,并减缓病的进展.
研究的目的:
- 审查当前和新兴的抗炎治疗策略,以管理慢性病和相关心血管风险.
- 突出正在进行的临床试验,调查CKD患者炎症途径内的新目标.
主要方法:
- 对最近和正在进行的临床试验的审查,重点是针对慢性病患者的特定炎症媒介和通路.
- 检查治疗方法,包括介质素-1 (IL-1) 和IL-1受体抑制剂,介质素-6 (IL-6) 和IL-6受体抑制剂,NLRP3炎症酶抑制剂,核因素红色素2相关因子2 (Nrf2) 激活剂和老化剂.
主要成果:
- 几种抗炎标,包括IL-1,IL-6,NLRP3炎酶,Nrf2和老化剂,正在为CKD患者的临床试验中进行积极的研究.
- 这些试验旨在评估这些新型治疗方法在降低动脉样硬化心血管疾病风险和减缓病进展方面的疗效.
结论:
- 针对炎症通路提供了一个有前途的途径,用于管理CKD及其心血管并发症.
- 尽管有前途的研究,这些抗生素治疗的临床实施仍然存在挑战和考虑,正在进行的第三阶段试验的结果尚未公布.
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