在自闭症谱系障碍中灰色和白色物质的跨主体功能变异性
Hairong Xiao1, Lina Yang1, Yingzhuo Wan1
1School of Mathematics and Statistics, Hunan Normal University, Changsha 410006, China; Key Laboratory of Applied Statistics and Data Science, Hunan Normal University, College of Hunan Province, Changsha 410006, China.
Progress in neuro-psychopharmacology & biological psychiatry
|September 18, 2025
概括
自闭症谱系障碍 (ASD) 在灰色和白质中表现出不同的功能连接性. 这些与症状严重程度相关的差异可以作为ASD诊断的生物标志物,并揭示遗传基础.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 生物标志物发现发现
背景情况:
- 自闭症谱系障碍 (ASD) 的特点是显著的生物异质性.
- 以前的研究主要集中在组级分析上,忽视了功能连接 (IVFC) 中的主体间的变异性.
- 了解ASD中的白质IVFC (WM-IVFC) 是至关重要的,但其机制和遗传影响仍然不清楚.
研究的目的:
- 调查与典型对照组 (TC) 相比,ASD患者的灰色物质IVFC (GM-IVFC) 和WM-IVFC的个体间变异性.
- 探索IVFC变化与ASD症状严重程度之间的关联.
- 通过机器学习评估GM-IVFC和WM-IVFC的诊断潜力,并通过转录组神经成像分析检查它们的遗传基础.
主要方法:
- 利用来自ABIDE II数据库的272名自闭症患者和368名TC患者的休息状态功能磁共振成像 (fMRI) 数据.
- 在两组之间比较GM-IVFC和WM-IVFC,将它们与症状严重程度相关联,并使用支持矢量机 (SVM) 模型进行诊断评估.
- 通过将IVFC变异与区域基因表达数据相关联,进行了转录组神经成像分析.
主要成果:
- 在GM-IVFC和WM-IVFC中,大脑分布不均.
- 患有自闭症的个体在默认模式和注意力网络中显示出GM-IVFC的增加,在质体内和上额头尾囊中显示出WM-IVFC的改变.
- IVFC的变化与症状严重程度有显著的关联,SVM组合模型达到77%的准确性. 转基因-IVFC变化与感官器官形态发生基因有关,而WM-IVFC变化与天体细胞通路有关.
结论:
- 在ASD中,GM-IVFC和WM-IVFC扮演着互补的角色.
- 这些IVFC措施显示出作为ASD生物标志物的潜力.
- 这些发现为导致ASD的遗传和神经生物学因素提供了新的见解.
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