化学多样性,受体结合亲和力和植物大麻素的药理学:对神经元机制的洞察
Claudio Marcos Queiroz1, Laura de Oliveira Koren1, Camila Rayane Pereira da Silva1
1Brain Institute, Federal University or Rio Grande do Norte, Natal, Brazil.
这项研究比较了五种关键的大麻化合物,发现THC和CBN强烈地与CB1/CB2受体结合,而其他如CBD与不同的点相互作用. 对不太常见的大麻素进行研究是必要的,因为它们的治疗潜力.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 大麻研究 大麻研究
背景情况:
- 大麻sativa产生超过100种植物性大麻素,但大多数是微量存在的.
- 了解这些化合物的结构和功能是释放大麻治疗潜力的关键.
- 最近出现的高CBD化学变异表明,杂交导致的遗传漂移.
研究的目的:
- 审查五种代表性植物性大麻素的结构,生化和药理特征:CBG,CBC,CBD,Δ9-THC和CBN.
- 分析化学物质的特征和受体结合 afinities.
- 探索尚未探索的植物大麻素的治疗潜力.
主要方法:
- 对CB1,CB2和其他神经元受体的结合亲缘关系 (Ki) 的系统审查和元分析.
- 巴西种植的品种和种子银行数据的染色学分析.
- 对临床前药理学证据的审查.
主要成果:
- Δ9-THC和CBN对CB1和CB2受体具有很高的亲和力.
- 与Δ9-THC和CBN相比,CBG,CBC和CBD对CB1 / CB2的亲和力是10-100倍低的.
- 非心理类植物性大麻素可能通过非正规的标 (GPR55,TRPV1,TRPM8) 起作用.
结论:
- 植物性大麻素之间的微妙结构差异导致明显的生理效应.
- Δ9-THC和CBD的结合亲和力显著不同,支持不同的治疗机制.
- 对未被充分探索的植物性大麻素进行进一步的研究对于发现新的治疗应用至关重要.
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