相关实验视频

Updated: May 12, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

一个严重的双边视神经炎病例和一个在怀孕期间的Tumefactive Demyelinating损伤

Ryo Sasaki¹, Yoshiaki Takahashi¹, Mizuki Morimoto¹

¹Department of Neurology, Kagawa Prefectural Central Hospital, Japan.

Internal medicine (Tokyo, Japan)

|September 18, 2025

概括

本案例研究强调了在怀孕期间治疗严重的视神经炎和瘤活性脱髓化病变的方法. 在初始治疗失败后,Ofatumumab (OFA) 证明有效地稳定了病变和症状.

科学领域:

神经免疫学神经免疫学
产科产科产科产科产科
脱线性疾病脱线性疾病

背景情况:

视神经炎 (ON) 和瘤性脱髓化病变 (TDLs) 是影响中枢神经系统的炎症性疾病.
由于对胎儿的潜在风险和改变母亲生理学的原因,在怀孕期间对这些疾病的管理存在独特的挑战.

研究的目的:

描述怀孕患者的临床表现和管理,同时出现严重的双边ON和TDL.
评估ofatumumab (OFA) 在怀孕期间治疗这种罕见疾病的疗效和安全性.

主要方法:

一个病例报告,一名40岁的孕妇经历了严重的双边ON和TDL.
治疗涉及初始疗法,包括静脉注射甲基普雷迪尼索隆,血交换和静脉注射免疫球蛋白.
随后的治疗是重复的类固醇脉冲疗法,接着是共享决策后的ofatumumab (OFA).

主要成果:

最初的治疗部分改善了视神经炎,但未能阻止TDL扩张和症状进展.
对Ofatumumab (OFA) 的使用导致病变扩大停止,没有进一步的症状恶化.
患者在怀孕期间耐受了OFA,没有报告的不良反应.

结论:

在怀孕期间严重的ON和TDL的同时发生是罕见的,并且难以管理.
当传统疗法不足时,Ofatumumab (OFA) 可能是孕妇TDL的可行的治疗选择.
在患有神经疾病的孕妇患者中,共同决策对于优化治疗策略至关重要.

关键词:

的一个atumumab.视神经炎是一种视神经炎.怀孕怀孕怀孕怀孕怀孕共享决策的共同决策.瘤活性脱髓化损伤

更多相关视频

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

相关概念视频

Bacterial Meningitis I: Introduction

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...

Encephalitis l: Introduction

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...

Encephalitis ll: Pathophysiology

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...