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动脉样硬化冠状动脉疾病患者的抗炎症策略

Antonino Imbesi¹, Antonio Greco¹, Davide Capodanno¹

¹Division of Cardiology, Azienda Ospedaliero-Universitaria "G. Rodolico-San Marco", University of Catania, Catania, Italy.

Expert review of cardiovascular therapy

|September 18, 2025

概括

持续的炎症导致动脉样硬化中的残留心血管风险,即使降低了最佳的胆固醇. 了解心肌梗塞后的急性和慢性炎症是针对性抗炎疗法的关键.

科学领域:

心血管医学心血管医学
免疫学免疫学免疫学
炎症研究炎症研究

背景情况:

动脉样硬化是冠状动脉疾病 (CAD) 的主要原因,越来越多地被认为是一种炎症性疾病,而不仅仅是脂质驱动的.
尽管有效降低低密度脂蛋白胆固醇 (LDL-C),但由于持续的炎症,许多患者面临剩余的心血管风险.
了解动脉样硬化进展和斑块破坏稳定的基础炎症过程对于改善患者的治疗结果至关重要.

研究的目的:

审查炎症在动脉样硬化和急性心肌梗塞 (AMI) 中的作用.
探索心血管风险分层的新兴生物标志物.
总结当前和正在研究的抗炎疗法用于CAD.

主要方法:

在PubMed,Web of Science和Cochrane数据库中进行全面的文献搜索,截至2025年7月.
分析炎症在斑块进展和不稳定中的作用.
审查当前和新型抗炎疗法和风险分层生物标志物.

主要成果:

炎症在动脉样硬化斑块的进展和不稳定中发挥着中心作用,导致急性心肌梗塞 (AMI).
新兴的生物标志物显示出改善心血管风险分层的希望.
目前和试验中的抗炎疗法为管理残留风险提供了潜力,重点是区分急性和慢性后AMI炎症.

结论:

抗炎疗法已经推进了心血管预防,但患者选择和目标识别方面的挑战仍然存在.
新型成像和人工智能驱动的模型正在为个性化抗炎策略铺平道路.
未来的研究应该优先考虑针对有害炎症的基于精度的方法,同时保持有益的免疫反应,以获得最大的临床益处.

关键词:

抗炎疗法是一种抗炎疗法.科尔奇辛 (Colchicine) 是一种可怕的药物.炎症生物标志物炎症生物标志物互乐金-6是其中的一种.脂蛋白 (a) 是一种蛋白质周围的周周脂肪组织组织.精准医学是一门精准医学.剩余的炎症风险剩余的炎症风险

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