相关实验视频

Updated: Jan 17, 2026

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse
03:52

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse

Published on: March 2, 2018

10.8K

在体内基础编辑的优化恢复了DFNA15小鼠模型中的听觉功能.

Man Wang1,2, Ziyu Zhang1, Xiaohan Wang1

  • 1Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Southeast University, Nanjing, China.

Nature communications
|September 18, 2025
PubMed
概括

基因编辑成功地通过精确纠正POU4F3基因突变,在遗传性聋 (DFNA15) 的小鼠模型中恢复了听力. 这种腺基编辑器疗法为遗传性听力损失提供了一个有前途的新疗法.

更多相关视频

Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane07:32

Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane

Published on: March 16, 2015

17.1K
Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice09:34

Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice

Published on: May 25, 2018

11.6K

相关概念视频

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
16.0K