Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

3.8K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.8K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

803
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
803
Equilibrium and Balance01:15

Equilibrium and Balance

6.3K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
6.3K
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

2.1K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
2.1K
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

1.4K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
1.4K
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

6.9K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
6.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Genetically Predicted Associations of CX3CL1 and UMOD with Acute Kidney Injury Risk: Evidence from Mendelian Randomization and Clinical Validation.

Journal of inflammation research·2026
Same author

Shared and culture-specific brain networks for emotional facial discrimination: Evidence from predictive modeling.

Neuropsychologia·2026
Same author

A self-perpetuating neuron-intrinsic GSDMD-mtDNA-AIM2 inflammasome axis drives neuronal pyroptosis and cognitive impairment after traumatic brain injury.

Frontiers in immunology·2026
Same author

The timing of visual selective attention in fronto-parietal network: TMS behavioral and brain structural evidence.

Neuroscience·2026
Same author

The role of inferior frontal gyrus in emotion regulation: Evidence from fMRI and tDCS investigation.

International journal of psychophysiology : official journal of the International Organization of Psychophysiology·2026
Same author

Modeling and Simulation of Mass Transfer in Food Processing: Recent Advances in Governing Equations, Workflow, and Applications.

Foods (Basel, Switzerland)·2026

相关实验视频

Updated: Jan 17, 2026

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography
07:51

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography

Published on: September 22, 2011

29.4K

高血压和头之间的因果关系:孟德尔的随机化研究.

Linrong Wu1, Yiming Shen2, Tian Li3

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, The Affiliated Lihuili Hospital, Ningbo University, Ningbo, China.

Current neurovascular research
|September 19, 2025
PubMed
概括

高血压增加了发作的风险,特别是良性发性位置 (BPPV) 和外围. 这项遗传研究表明存在因果关系,有助于早期预测.

关键词:
在高血压的高血压.门德尔的随机化.头 (vertigo) 是一种令人头的情况.

更多相关视频

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.2K

相关实验视频

Last Updated: Jan 17, 2026

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography
07:51

Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography

Published on: September 22, 2011

29.4K
Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.2K

科学领域:

  • 遗传学 遗传学 是一个
  • 流行病学 流行病学
  • 心血管研究研究心血管研究

背景情况:

  • 有限的遗传研究存在于高血压在的因果作用.
  • 观察性研究在确定像BPPV这样的子亚型的因果关系方面面临设计限制.
  • 高血压对前庭功能障碍的影响需要进一步的遗传研究.

研究的目的:

  • 使用双样本门德尔随机化 (MR) 方法调查高血压和之间的潜在因果关系.
  • 分析高血压与总,中心,BPPV和其他外围之间的关联.
  • 为高血压提供遗传证据,作为特定的风险因素.

主要方法:

  • 采用了利用全基因组关联研究 (GWAS) 数据的两样 MR 设计.
  • 确定了53个与高血压相关的全基因组显著SNP作为仪器变量.
  • 应用各种MR方法 (IVW,MR-Egger,加权中位数,简单模式) 来评估因果关系.

主要成果:

  • 在高血压和总之间发现了显著的积极关联 (OR:1.16).
  • 高血压与BPPV (OR:1.12) 和其他外围的风险增加有显著的联系 (OR:1.19).
  • 在高血压和中心之间没有观察到显著的关联 (OR:1.15).

结论:

  • 遗传证据支持高血压和,特别是BPPV和外围之间的积极关联.
  • 高血压可能通过血管变化和随后的组织缺氧导致前庭功能障碍.
  • 调查结果有助于了解风险因素和潜在的早期预测策略.