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大奶粉作为对花生过敏的保护因素:来自出生队列的证据

Maheshwar Bhasin^1,2, Matthew Cooper², Patricia Macchiaverni^1,2

¹Larsson-Rosenquist Foundation Centre for Immunology and Breastfeeding, School of Medicine, University of Western Australia, Perth, Western Australia, Australia.

|September 19, 2025

概括

部分母乳养,即婴儿与母乳一起获得配方奶粉,与花生和多种食物过敏的风险更高有关. 确保足够的胆乳摄入量可能对预防新生儿过敏至关重要.

科学领域:

免疫学免疫学免疫学
儿科儿科儿科
过敏研究研究过敏

背景情况:

食物过敏对生活质量构成重大风险,并可能危及生命.
早期的营养习惯对于免疫发育和过敏预防至关重要.
牛乳含有丰富的生物活性化合物,在婴儿的免疫和肠道健康中起着至关重要的作用.

研究的目的:

调查部分胆乳养 (PCF) 是否会增加食物过敏的风险.
为了确定大奶粉摄入量和过敏结果之间的关联.
早期识别可改变的食物过敏风险因素.

主要方法:

研究了来自澳大利亚ORIGINS队列的666对母婴对.
在头3天内将新生儿分为完全母乳养 (ECF) 或部分母乳养 (PCF) 组.
在12-18个月使用皮肤刺伤测试和母亲报告评估IgE介导的食物过敏.

主要成果:

46%的婴儿被部分母养 (PCF).
在PCF的婴儿中,花生过敏的风险显著增加 (aOR 4.47) 和多种食物过敏的风险显著增加 (aOR 11.44).
婴儿在72小时内每天接受≥9次大奶粉养的婴儿中没有发生任何花生过敏病例,无论配方是否使用.

结论:

部分胆乳养是一种被忽视的花生和多种食物过敏的风险因素.
促进大奶粉养对于预防新生儿过敏至关重要.
基于乳母乳的疗法可能有利于高风险的婴儿.

关键词:

食物过敏食物过敏营养营养营养营养儿科儿科儿科预防预防预防

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